Volume 14
Number 1 January 2010Role of Flutamide on Acinar Diameter in Testosterone Induced Prostatic Hyperplasia
DOI: https://doi.org/10.47648/jmsr.2010.v1401.01
Rahman Md. A1 , Naushaba H2 , Ahmed Md. N3 , Rahman Md. M4
Abstract
Testosterone is the male sex hormone responsible for growth of secondary sexual characters and accessory sex organs. Despite the effectiveness as a male sex i101711011C, testosterone causes benign preemie hyperplasia (BPH) resulting in urinary dysfinction. On the other hand. Bromide is a pure anthestosterone, which blockw the effects of dihydnoestosterone (DHT)at the testosterone receptor and presents BM. The objective of the study was to observe the effects of flutamide on testosterone induced promatic hypetplasia in Long Evans rats. This experimental study was carried or I e Department of Anatomy. Sir Salimullah Medical College. Dhaka from January to December 2006. Forty five matured male Long Evans rats of age 8-10 weeks and weighing 200-300 gnu were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group B was testosterone treated group and Group C was testosterone and flu:amide treated group. Comparative study in different groups were done microscopically. There was significant reduction (p<0.001) qproslatic hypetplasia. The mean diameter of acini of prostate in flutamide treated rats was loner than the testosterone treated rats. It can be concluded from this study that flatamide is an effective drug against testosterone induced prostatic hyperplasia.
Keywords:
- Associate Professor, Department of Anatomy
- Professor and Head, Department of Anatomy
- Lecturer, Department of Anatomy
- Lecturer. Department of Anatomy