Volume 7

Number 2 July 2006

Effect of Crude Nigella sativa Linn. (kalajira) on Gentamicin-induced Nephrotoxicity

DOI: https://doi.org/10.47648/jmsr.2006.v0702.02

Begum N A1 , Dewan Z F2 , Nilufer3 , Mamun M I R4

Abstract

Reactive omen speriev are involred in grimalkin nephrotaricity. This study investigated whether mhniniaration of crude Nigel: swim (Rat lira) ameliorates gentatnivin.intInced nephrolovieity. Crude N. mita powder am Oren orally t 10 gen/kg/day mixed in sad dr:mated Waal ea pox,, paa. real canamorilaea treatment for seven dap in gentandrin.induced nephnnavic rats ( 100 ni.e/keday far sevot days). Nephrom.virity was molualed bithelimirrelly la waxwing the aurrearrtatiaa v of ernrairtiole and neva in wain and minced ghdathione tGS1I) in kidney cortex. The ,sits indicated that geonamicin significant", ineâ– rasal the concentrations of' creation:le and urea. and decreased GSH. Adminiararion of crude N. saliva in geniamicin.indetnyt nephroloric ram ay pre-. post. and conmaitant unman' demonsmIted statistically significant amelioration of the biochemical indices of gents orephrolovicity. This Inneliaration 4,eephentaricity teas more sigealialal is pon.aratinent poop than the roncanitatuly awed tad the pretreatment syntax. The result suggests that male: . mato may he vsef,d in anclioratinp signs 4,entannein nephrotarieity in rats.

Keywords:


  1. Assistant Professor of Pharmacology

    Holy Family Red Crescent Medical College, Dhaka

  2. Associate Professor of Pharmacology

    Bangabandhu Sheikh Mujib Medical University, Dhaka

  3. Professor, Departmen of Chemistry

    University of Dhaka, Dhaka

  4. Assistant Professor, Department of Chemistry

    University of Dhaka, Dhaka

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Volume 7, Number 2 July 2006
Page: 45150