Sympathetic Nerve Function Status in Type 2 Diabetes Mellitus: Relationship with Glycaemic Status and Duration

DOI: https://doi.org/10.47648/jmsr.2008.v1102.03

Alam Md. K1 , Begum N2 , Molla M. H.3 , Begum S4

Abstract

The study was designed to observe the sympathetic nerve fiarction status in recently diagno.ved and long duration (10-20 years) type 2 diabetic subjects in order to assess whether the duration of diabetes has any influence on the sympathetic nerve firoudion. The present SlUdy was carried on also to obtain a base line dam in the form of a set of normal reference willies of cardiovascular reflex rest parameters in a selected group of adult Bangladeshi population. For this purpose 47 type 2 diabetic subjects were included in ors groups, group A consisted 1,1. 25 recently diagnosed diabetic subjects and group B consisted of 22 subjects having duration of diabetes for 10.20 years. Bventy five age and BAB nratched healthy subjects were included in group C (non-diabetic) for control and also to observe the baseline data. Sympathetic nerve fraction was a.vseused by two simple nominversive cardiovascular reflex teals. Tests item .orstained handgrip tests and blood pressure response to standing. The normal or reference values obtained from the norm-diabetic subjects of the present study were compared to those in) published reference values of different poptelatiorr around the world and no apparent differences trvre observed. Glycaemic vanes of the diabetic subjects were more or less controlled. Cardiovascular reflex test for sympathetic function were finind no be significantly a:throat in long duralion diabetic group in comparison to control group and recently diagnosed diabetic group. Front this study it is concluded 'hat sprthathetic nerve finwrion seems to be affecied at rho sane glyciremic status in longer duration of diabetes.

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  1. Assistant Professor and Ulead, Department of Physiology

    Ibn Sina Medical College, Dhaka

  2. Chairman, Department of Physiology

    Bangabandhu Sheikh Mujib Medical University, Dhaka

  3. Professor and Head, Department of Physiology

    Holy Family Red Crescent Medical College, Dhaka

  4. Associate Professor, Department of Physiology

    Bangsbandhu Sheikh Mujib Medical University, Dhaka


Volume 11, Number 2 July 2008
Page: 23-30