The patient of chronic arsenic toxicity shows oxidative stress. To overcome the oxidative stress. several antioxidants such as fl-carotene, ascorbic acid, attocopherol, sine and selenium had been suggested. in the present study. universal antioxidant (both water and lipid soluble antioxidant) alpha-lipoic acid was used to examine the effectiveness of this thin( on arsenic metabolism. Alpha-lipoic acid increases the inethylation of inorganic arsenic and releases nionomethylarsenic acid (MMA) and dimethylarstatic acid (DMA) from the haracellular pool. These results suggest that alpha-lipoic acid increases metabolism of arsenic thereby reduces the concentration of arsenic from arsenic-loaded isolated liver tissues of rat.