A prospeahw study was carried out to find out dw anti-inflammatory eels of the ethanolic extract of ground seeds of Nigella saliva in inflanuned rats at the Department of Pharmacology and Therapeutics. Dhaka Medical College. during the period from January to December 2008. effect was compared among sixty tong Evan Norwegian rats with reference standard aspirin mu! hydrocortisone. Acute inflammtion uws induced by Carrafrenan inject at the sub-pplantar surface of the hind paw of rat. Ethanol extract of ground seed of Nigella aspirin, hydrocortisone and normal saline (as control) were administered to evaluate anti-inflammatory ejects. The and-inflammatory effects (acute) measured by 'inhibited oedema formation' were 43.79% by Nigella saliva. 40.52% by aspirin, 47.71% by hydrocortisone. Again chronic inflammation ~teas induced by implantation of a sterile cotton pellet in rat's groin region for 14 days and treated with Nigella saliva extract, aspirin, hydrocortisone curd normal saline. The anti-inflammatm effects (chronic) were measured by weighing cotton pellet lo evaluate 'inhibited gramdonw.formation' and were 41.42%, 27.67% and 38.58% respectively. Meweover, Nigella swim extract was administered in two different  doses (250mg/kg and 500 mg/kg body weight) and significant anti-inflammatory effect was observed in' the higher dose.