Foot complications are major cause of morbidity and mortality in patients with diabetes mellitus. Vacuum-assisted closure (VAC) therapy is a popular treatment for the management of both acute and chronic wounds in diabetic foot complications. The study compared between VAC therapy versus conventional dressings in the management of diabetic foot ulcers. To compare the effectiveness and safety between Vacuum-assisted closure versus conventional dressings in the management of diabetic foot ulcers this prospective comparative study was conducted among 68 diabetic patients in BIRDEM General hospital and Shaheed Khaleq Ibrahim general Hospital in Dhaka in 2 years. Changes in wound dimension, disappearance of wound discharge, presence of wound granulation ,infection status, amputation rate, skin graft, successfully healed andpatientssatisfactionwere compared between 2 groups. By VAC therapy healing was achieved rapidly and effectively.23wounds was closed by split-skin grafting and 7 wounds by secondary closure and wound of 3 patients healed spontaneously. The average length of treatment with VAC therapy was 23.3 days. Wounds of 33 patients were satisfactorily granulated and cleared of bacterial infection at the end of VAC therapy.ln conventional group 2patients had spontaneous closure and 20 patients need split skin graft. VAC therapy group one patient need amputation but in conventional group 7 patients ended up with amputation. VAC appears to be more safe and effective compared to conventional dressings in the treatment of diabetic foot ulcer.