Volume 27

Number 2 July 2017

Biochemical Profile and Degree of Liver Involvement in Dengue Fever

DOI: https://doi.org/10.47648/jmsr.2017.v2702.01

Mili N Y1 , Sikder S2 , Basar A3 , Hoque E4

Abstract

Dengue disease has emerged globally as the most frequent and medically relevant viral infection transmitted by mosquito bite. Acute hepatitis is a manifestation of dengue virus infection. This study shows the impact of dengue on liver function was studied by biochemical tests on 80 patients out of them 53 male (age 42±12 yrs) and 27 female (age 39±13 yrs). The patients were diagnosed as dengue fever and were admitted in Holy Family Red Crescent Medical college Hospital from June 2014 to December 2016. All the patient were diagnosed by anti-dengue IgM positive by ELISA method. Abnormal level of aspartate aminotransferase (ASV, alanine aminotransferase (ALT), bilirubin, alkaline Phosphatase (Alp), gamma-glutamyl transferase (G-GT) and albumin and urinary albumin were observed in 82.5%, 82.5%, 47.5%, 38.75%, 71.25% ,66.25% and, 76.25% of the patients respectively. It is concluded that dengue fever may cause hepatic injury and transaminase elevation similar to that in patients with conventional viral hepatitis. In epidemic or endemic areas, dengue fever should be considered in the differential diagnosis of acute hepatitis.

Keywords:


  1. Assistant Professor, Department of Physiology

    Holy Family Red Crescent Medical College, Dhaka

  2. Assistant Professor, Department of Nephrology

    Holy Family Red Crescent Medical College, Dhaka

  3. Resident Medical officer, Department of Nephrology

    Holy Family Red Crescent Medical College, Dhaka

  4. Professor and Head, Department of Nephrology

    Holy Family Red Crescent Medical College, Dhaka

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Volume 27, Number 2 July 2017
Page: 44991