Volume 27
Number 2 July 2017Clinico-pathological Correlation with Liver Enzymes in Dengue Infection
DOI: https://doi.org/10.47648/jmsr.2017.v2702.05
Kamal A H M1 , Mollah K H2 , Khuda K E 3 , lslam A4 , Sultana N5 , Jahan Q A6
Abstract
Dengue infection is a major vector borne disease. The classical signs and symptoms include high fever, severe headache, chill, and rash. Atypical manifestations of dengue infection with hepatic involvement are frequently reported, ranging from mild elevations of liver enzymes to acute liver failure. Analysis of 110 serologically confirmed cases of dengue infection in Holy Family Red Crescent Medical College hospital a tertiary care hospital was done. Patients with normal aminotransferase levels were categorized into Grade A, patients with at least one of the enzymes raised above normal but less than 3 times were categorized into Grade B, those with at least one of the enzymes elevated more than 3 times but less than 10 times were graded as C, and those with elevations more than 10 times as Grade D. 83.7% patients had alterations of transaminase levels, with 45.5% categorized into grade b, 30.9% into grade C, and 7.3% into grade D or acute hepatitis (P value 0.224). Rise of aspartate aminotransferase (AS7) levels were higher compared to the levels of alanine aminotransferase (AL7). Liver damage with alteration of aminotransferases is a common manifestation of dengue infection and also valuable markers for monitoring these patients.
Keywords:
- Professor and Head, Department of Medicine
- Assistant Professor, Department of Medicine
- Registrar, Department of Medicine
- Resident Medical Officer, Department of Medicine
- Resident Medical Officer, Department of Medicine
- Resident Medical Officer, Department of Medicine