Volume 13

Number 2 July 2009

Insulin Resistance and Inflammatory Status Among Rheumatoid Arthritis Patients in Bangladesh

DOI: https://doi.org/10.47648/jmsr.2009.v1302.01

Alam F1 , Azad K2 , Sultana S3 , Habiba T4 , Nargis W5 , Khanam M6

Abstract

This study was done to evaluate the association of insulin resistance and inflammatory Hants in Bangladeshi population. Eighty seven subjects, collected frost the outpatient department of Bangabandhu Sheikh Mujib Medical University, where 45 were rheumatoid arthritis (RA) patients and 42 controls. The RA patients showed significantly higher jotting blood sugar. fisting instilin and ha-CRP level, when compared to controls. There was no significant difference between RA subjects and controls for B-cell function assessed by Homeostasis Model Assessment (HOMA%B), insrdin sensitivity assessed by Homeostasis Model Assessment (HOMA%S) and insulin resistance (IR). Among RA subjects, CRP and IR level improved after treatment. No significant correlation was found between CRP and IR. CRP and HOMA%S. and CRP and HOMA%B. In Bangladeshi RA subject. insulin sensitivity has been found to be preserved. Insulin resistance is not a prondnent feature in Bangladeshi RA subjects and CRP does not have any correlations with insulin resistance in Bangladeshi RA subjects. The improvement of the chronic inflammatory condition induced by steroid treatment seems to be associated with improved IR status.

Keywords:


  1. Assistant Professor, Department of Biochemistry

    Uttara Adbunic Medical College and Hospital, Dhaka

  2. Associate Professor, Department of Biochemistry

    Shahabuddin Medical College and Hospital, Dhaka

  3. Assistant Professor, Department of Microbiology

    Shahabuddin Medical College and Hospital, Dhaka

  4. Associate Professor, Department of Physiology

    Shahabuddin Medical College and Hospital, Dhaka

  5. Assistant Professor, Department of Biochemistry

    Uttara Adbunic Medical College and Hospital, Dhaka

  6. Assistant Professor, Department of Pharmacology

    Shahabuddin Medical College and Hospital, Dhaka

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Volume 13, Number 2 July 2009
Page: 44993