Volume 13

Number 2 July 2009

Role of Finasteride on Testosterone Induced Prostatic Hyperplasia in Long Evans Rats

DOI: https://doi.org/10.47648/jmsr.2009.v1302.03

Rahman Md. A1 , Naushaba H2 , Khan N A3 , Rahman N4

Abstract

Tesrostemne is the main male sex hormone responsible for growth of sexual character and accessory an organs. Despite its effectiveness as a male sex honotone. it causes benign prostatic hypmplasia (PPH) resulting in urinary dysfitriction. On the other hand. finasteride is a 4-amstroid which inhibit the hyperplastic effect of testosterone and benign prostatic loperplasia. The objective of the study was to observe the effects of finasteride on testosterone induced promatic fivperplasis in Long Evans rats. This experimental study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka from January to December 2006. Total 45 matured male long Evans rats of age 8-10 weeks and weighing 200-300 gins were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group 8 was testosterone treated group and Group C was testosterone and finasteride treated group. The rats were sacrificed on the eleventh day. It was concluded that finasteride is an effective drng successfidly inhibiting the testosterone induced prostatic hyperplasia.

Keywords:


  1. Associate Professor, Department of Anatomy

    Holy Family Red Crescent Medical College, Dhaka

  2. Professor and Head. Department of Anatomy

    Sir Salimullah Medical College, Dhaka

  3. Lecturer, Department of Anatomy

    Holy Family Red Crescent Medical College, Dhaka

  4. Lecturer, Depariment of Biochemistry

    Holy Family Red Crescent Medical College, Dhaka

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Volume 13, Number 2 July 2009
Page: 13-18