Volume 21

Number 2 July 2013

Case Control Study on Platelet Aggregation, Fibrinogen and Von Willebrand Factors in Diabetis Patients

DOI: https://doi.org/10.47648/jmsr.2013.v2102.01

Huque M1 , Ahmed T2 , Zinnat R3 , Bhuiyan Md. M4 , Mahtab H5

Abstract

Vascular complications are common in diabetes mellitus and are leading causes of morbidity and mortality due to the disease. Platelet hyper-aggregation and coagulation factor abnormalities have been implicated in the increased prevalence of vascular complications. The cross sectional analytical study was done on 50 young, non-obese, normo-to hypoinsulinemic normotensive and untreated Bangladeshi diabetic patients to help in understanding the pathogenesis of platelet hyper-aggregation and coagulation factor abnormalities in diabetes mellitus for their platelet aggregation response to ADP, plasma fibrinogen and Von Willebrand Factors (vWF). Mean age was 23.7 ± 2.26 years in control and 24.33 ± 3.29 years in patients. The lipid profile, C-peptide, C-peptide: glucose and other anthropometric measurements of the diabetic and control subjects were also measured to find out any possible correlation. Platelet aggregation was measured by optical aggregometry, plasma vWF and plasma fibrinogen were measured by radial immuno-diffusion method. The platelet aggregation with ADP in diabetics was found to be significantly higher in diabetics 76.56 ± 16.92 compared to controls 62.90 ± 12.35 (P< 0.27). Plasma fibrinogen were found to be significantly higher in young diabetics 1075.90 mg/L compared to the non-diabetic counterparts and plasma vWF 1.372 iu/ml in diabetic patients. In young diabetics, platelet hyperaggregation and coagulation factor abnormalities appear quite early and seem to play important role in the natural history of vasculopathy in diabetes mellitus. Diabetic condition (as evidenced by hyperglycemia), by itself, may create platelet hyperaggregation and coagulation factor abnormalities, however, there seems to be no straightforward relationship between those abnormalities and the degree of hyperglycemia.

Keywords:


  1. Associate Professor (cc), Department of Diabetes and Endocrinology

    Holy Family Red Crescent Medical College, Dhaka

  2. Professor, Department of Endocrinology

    Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorders (BIRDEM), Dhaka

  3. Associate Professor, Department of Biochemistry and Cell Biology

    Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorders (BIRDEM), Dhaka

  4. Professor and Head, Department of Paediatrics

    Holy Family Red Crescent Medical College, Dhaka

  5. Chairman

    National Healthcare Network (NEIN)

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Volume 21, Number 2 July 2013
Page: 44993