Perinatal asphyxia causes about 0.92 million newborn death annually world wide and it is about 21% of the neonatal mortality in Bangladesh which is second to death due to severe infections and its related death. The Retrospective observational study was done to evaluate the outcome of perinatal asphyxia in Neonatal Intensive Care Unit (NICU) of Holy Family Red Crescent Medical College Hospital.from October 2013 to December 2014. Total 327 asphyxiated neonates full filling the inclusion criteria admitted in NICU (both in born & out born, term and preterm). Out of these 59% male patients and 41 % female term, 22% of the asphyxiated patient term unit and 77% preterm. Total deaths among these were 27. Out of these 2 deaths belongs to term units also had some associated neonatal infections and 25 deaths belongs to preterm who had also some other complications related to prematurity. The study results show that predictors of survival were mode of delivery, place of birth and resuscitation at birth. Elective caesarean section was associated with improved outcomes. The study confirms that perinatal asphyxia remains a significant problem at HFRCMCH. The high overall survival and survival after NICU admission provide a benchmark for further care.