Self-medication is a gradually increasing entity in a healthcare system. It leads patients towards greater independence in taking decisions about management of minor illnesses. It ensures access to medication and limits delayed diagnosis, worsening of disease evolution, the cost burden of drugs in comparison to prescribed drug. The aim of the study was to evaluate the prevalence of the use of NSAIDs as in the form of analgesics for self-medication with their associated risks especially GIT symptoms. This cross-sectional study was done at Holy Family Red Crescent Medical College Hospital, Dhaka, July 2018 to December 2018 for 6 months among the patients who registered to visit Orthopaedic OPD for their musridoskeletal problems. A pretested and validated questionnaire was used to collect data. There were 97% response rate recorded. The study included 571 randomly selected patient aged between 20 to75 years, of which 55.3% were from urban areas versus 44.7% from rural areas, females being dominant (69.32%). The drugs which was surveyed, were used by 84.8% of the study population, in most cases the administration being made without prior professional advice. Of the 331 participants prom urban areas, 89% used the self-medication, compared with 58.31% in rural areas. Paracetamol (46.34%), followed by Ketorolac (24.47%) and Diclofenac (22.7%) are among the most widely used analgesics, both in urban and rural areas. The most frequent symptoms that required self-medication were: low back pain (urban and rural are), neck pain (predominantly urban) and knee joint pain (predominantly rural areas). Misuse of analgesics and anti-inflammatory drugs, both in urban and rural areas is a burning issue. The growing economy improvised urban and rural people to avail the medications without knowing the risks. Close monitoring, a multilevel venture between all concerned -patients, physicians and pharmacists to provide the supervised education and appropriate information on safe self-medication for the accomplishment of national goals, are suggested plan of action. It will maximize the benefit and minimize the risks.