Patients of chronic kidney disease on hemodialysis face varieties of challenges and comorbid conditions need regular assistance from family caregiver. Caregivers of end stage renal disease (ESRD) have to bear loads of patient's daily activities, cares, medication, carrying to hospital, managing their psycho-social and financial demands which impose additional stress and burden among them. The study was conducted to evaluate the effect of care giving of patients with ESRD and to analyze the factors associated with it This cross sectional, observational and descriptive type of study was conducted in the Department of Nephrology and Psychiatry of Holy Family Red Crescent Medical College during the period of July 2018 to June 2019. Fifty family caregivers of age more than 18 years providing care or assistance to a relative with ESRD on dialysis were included. The burden of the care giver was assessed by a verified and culturally adopted Bangla-version of 22 factor Zarit Burden Interview (ZBI-B) scale. Difference of burden was not statistically significant considering its sex, marital status, place of residence, education level, religion, relation with patient, living in same house with patient or duration of the care giving of the patients (p>0.05). In JO% cases care givers had little or no burden, 26% mild to moderate, 22% moderate and 2% severe burden. So, in Bangladesh caregiving to ESRD patients imposes no or little burden on majority offamdy caregivers.