Inflammation plays a major role in the initiation, progression & destabilization of atheroma. C-reactive protein (CRP) is a sensitive marker of inflammation, and elevated levels have been associated with future risk of myocardial infarction (MI). Risk of coronary heart disease & other forms of atherosclerotic vascular disease rises with plasma cholesterol concentration & in particular the ratio of total cholesterol to high density lipoprotein (HDL-C) cholesterol. Measurement of C- reactive protein (CRP) adds to the predictive value of total cholesterol (TC) and HDL cholesterol (HDL-C) in determining subsequent risk of first myocardial infarction. Methods: This cross-sectional analytical study was undertaken to observe association between high sensitive CRP and lipid profile level with chronic ischaemic heart disease and was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total 50 cases were selected purposively according to the selection criteria from the patients admitted in the Department of Cardiology, Dhaka Medical College Hospital with chronic ischaemic heart disease (IHD). Diagnosed IHD patients were taken as cases; age- & sex- matched 50 healthy subjects were taken as controls. Serum hsCRP and serum TC, TAG, LDL-C & HDL-C were measured in all study subjects. Results: The mean serum CRP concentration in cases and controls were 11.22+/-7.64 mg/dl and 1.72+/-0.98 mg/dl respectively. Mean serum TC, TAG, HDL-C and LDL-C in cases groups were 314+/-74 mg/dl, 288+/-60 mg/dl, 36+/-4 mg/dl, and 178+/-22 mg/dl respectively and in controls groups were 175+/-19 mg/dl, 118+/-12 mg/dl, 43+/-2 mg/dl & 126+/-11 mg/dl respectively. Serum hsCRP, Total Cholesterol, TAG & LDL-C were significantly higher in cases than control subjects. Serum HDL-C was significantly lower in cases than control subjects. Conclusions: The present study reveals that the patients of chronic ischaemic heart disease have been found to have close association of increased level of hsCRP and lipid profile.