Background and objective: The red cabbage (Brassica oleracea Linn var. capitata) is a leafy green biennialplant that contains beta-carotene, vitamin C and fibre. It is used in cooking for its nutritional value andhas known anti-inflammatory activity.This study compared the antiulcerogenic activity of Aqueous Extractof Brassica (AEB) oleracea var. capitata with Misoprostol.Materials and Method: Acute gastric ulcers wereinduced in albino rats by the oral administration of indomethacin. The gastroprotective potential of theAEB(250,500 and 1000 mg/kg body weight) was compared with Misoprostol (100μg/kg body weight). Results:Asignificant reduction in the mean number of lesions was observed in high dose AEB (0.83 ± 0.75) comparedwith indomethacin (4.00 ± 1.26). Mean number of lesions were similar in misoprostol groups (1.50 ± 0.55)and medium dose AEB (1.77 ± 0.41).No significant reduction in the mean number of lesions was observed inlow dose AEB (3.00 ± 0.63) compared with indomethacin (4.00 ± 1.26). Inhibition percentage was maximumin high dose AEB (97.71%) and minimum in low dose AEB (28.08%).Conclusions: The AEB demonstratedgood antiulcerogenic activities which justify the inclusion of this plant in the management of gastric disorders.Further experiments are underway to determine which anti-ulcer mechanisms involved in gastroprotection.