Histoid Leprosy: A Case Report


Rashid Md. A1 , Rahman Md. M2 , Ahmed S3 , Kabir Md. S4 , Kamaluddin Md.5


Histoid Leprosy is rare but most ancient bacterial disease in the history of mankind It is a chronic granulomatous inflammatory disease, primarily of the peripheral nervous system, skin, and reticuloendothelial system. It was first reported by Wade in 1963. Leprosy (Hansen's disease) is a chronic infectious disease which is diagnosable and curable if recognized early and treated adequately.The causativeagent of leprosy is Mycobacterium leprae which is only bacteria to infect peripheral nerves. Leprosy is characterized by a variety of abnormal immune responses. It depends on the integrity of the host's specific CMI response to the M. leprae and it may be genetically determined. Anti-leprotic Multidrugs Therapy (MDT) as recommended by WHO is now the standard and accepted method for leprosy control. Leprosy cannot be completely eradicated; it will disappear when the economic and cultural factors change, because leprosy is the thermometer of civilization. It commonly affects buttocks, back, face and extremities. It presents clinically as an erythematous or hypopigmented anesthetic patch and a thickened and/or tender cutaneous nerve trunk. Leprosy is also called Hansen disease. Leprosy is a great imitator of other skin diseases, and it can present with different morphological lesions, this is why an expert eye is needed to diagnose it. One of the important clinical presentations of leprosy is histoid leprosy, which is very difficult to diagnose due to different clinical and histopathological findings that mimic, e.g., a fibromatous disorder.


  1. Assistant Professor, Department of Dermatology

    Holy Family Red Crescent Medical College, Dhaka

  2. Associate Professor, Department of Dermatology

    Holy Family Red Crescent Medical College, Dhaka

  3. Assistant Professor, Department of Dermatology

  4. Professor & Head, Department of Dermatology

    National Medical College, Dhaka

  5. Consultant, Department of Dermatology

    Gopalgonj Sadar Hospital, Gopalgonj

Volume 28, Number 1 January 2018
Page: 39-42